Continuous cultures of fused cells secreting antibody of predefined specificity

@article{Khler1975ContinuousCO,
  title={Continuous cultures of fused cells secreting antibody of predefined specificity},
  author={G. K{\"o}hler and C. Milstein},
  journal={Nature},
  year={1975},
  volume={256},
  pages={495-497}
}
  • G. Köhler, C. Milstein
  • Published 1975
  • Biology, Medicine
  • Nature
  • THE manufacture of predefined specific antibodies by means of permanent tissue culture cell lines is of general interest. There are at present a considerable number of permanent cultures of myeloma cells1,2 and screening procedures have been used to reveal antibody activity in some of them. This, however, is not a satisfactory source of monoclonal antibodies of predefined specificity. We describe here the derivation of a number of tissue culture cell lines which secrete anti-sheep red blood… CONTINUE READING

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    Production of Monoclonal Antibodies
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