Continuous combination oral contraceptive pills to eliminate withdrawal bleeding: a randomized trial.

  title={Continuous combination oral contraceptive pills to eliminate withdrawal bleeding: a randomized trial.},
  author={Leslie Miller and James P. Hughes},
  journal={Obstetrics and gynecology},
  volume={101 4},
OBJECTIVE To compare bleeding profiles of a traditional 28-day oral contraceptive pill cycle with continuous administration. METHODS After a 28-day run-in cycle, women were randomized to either 28-day cycles (21 active pills and a pill-free week) or continuous use of the same 20 microg ethinyl estradiol/100 microg levonorgestrel formulation for 12 study cycles (336 days). The number of bleeding and spotting days were measured by daily diary. A subset underwent cycle 1 (n = 16), and nine (n… CONTINUE READING

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