Continuous cocaine administration produces persisting changes in brain neurochemistry and behavior.

@article{Zeigler1991ContinuousCA,
  title={Continuous cocaine administration produces persisting changes in brain neurochemistry and behavior.},
  author={Susanne Zeigler and Josh Lipton and Arthur W. Toga and Gaylord Ellison},
  journal={Brain research},
  year={1991},
  volume={552 1},
  pages={27-35}
}
Rats were administered either continuous cocaine, daily injections of cocaine, continuous amphetamine, or no drug for 5 days and then given a 30 day drug-free recovery period. When subsequently tested in open field, the daily cocaine injection animals were the most hyperactive whereas the cocaine pellet animals were the most fearful. In vitro autoradiography was then utilized to examine persisting changes in receptor binding for D2 ([3H]spiperone), D1 ([3H]SCH23390), benzodiazepine ([3H… CONTINUE READING
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