Continuous cocaine administration enhances μ- but not δ-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens

@inproceedings{Izenwasser1996ContinuousCA,
  title={Continuous cocaine administration enhances μ- but not δ-opioid receptor-mediated inhibition of adenylyl cyclase activity in nucleus accumbens},
  author={Sari E Izenwasser and Brett Heller and Brian M Cox},
  year={1996}
}
Cocaine alters opioid receptor densities in rat brain. To investigate the functional consequences of such opioid receptor changes, adenylyl cyclase activity was measured in rat nucleus accumbens and caudate putamen following continuous cocaine administration (50 mg/kg/day, 7 days). In the nucleus accumbens chronic cocaine led to an increase in both the number of μ-opioid receptors and the maximal inhibition of adenylyl cyclase activity by DAMGO ([d-Ala2,N-methyl-Phe4,Glyol]enkephalin). There… CONTINUE READING
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