Continuous cardiac output and hemodynamic monitoring: high temporal correlation between plasma TNF-alpha and hemodynamic changes during a sepsis-like state in cancer immunotherapy.

@article{Caorsi2003ContinuousCO,
  title={Continuous cardiac output and hemodynamic monitoring: high temporal correlation between plasma TNF-alpha and hemodynamic changes during a sepsis-like state in cancer immunotherapy.},
  author={Carlos Caorsi and E. Fern{\'a}ndez Quintana and Sergio H. Diaz Valdes and Carlos Mu{\~n}oz},
  journal={Journal of endotoxin research},
  year={2003},
  volume={9 2},
  pages={91-5}
}
Through continuous cardiac output monitoring, we investigated the temporal relationship between hemodynamic changes and plasma cytokines in a cancer patient who developed collateral sepsis to immunotherapy. A 52-year-old male with metastatic renal cell carcinoma received interleukin-2 (IL-2) infusion completing 72 h of administration. The patient developed 3 sepsis-like states including systemic inflammatory response syndrome (SIRS), shock, and multiple organ dysfunction syndrome (MODS… CONTINUE READING