Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats.

@article{Oitzl1998ContinuousBO,
  title={Continuous blockade of brain glucocorticoid receptors facilitates spatial learning and memory in rats.},
  author={Melly S. Oitzl and Marc F J Fluttert and Win Sutanto and Edo Ronald de Kloet},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 12},
  pages={3759-66}
}
Previously, a corticosterone surge associated with a learning task was shown to facilitate cognitive processes through brain glucocorticoid receptors (GR) while chronic overexposure to this stress hormone impaired cognition. In the present study we tested the hypothesis that opposing effects on learning and memory might also occur after either phasic or continuous blockade of brain GR by intracerebroventricular (i.c.v.) administration of the GR antagonist RU38486 (aGR). We used a Morris water… CONTINUE READING
52 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…