Continuous and scalable process for water-redispersible nanoformulation of poorly aqueous soluble APIs by antisolvent precipitation and spray-drying.

@article{Hu2011ContinuousAS,
  title={Continuous and scalable process for water-redispersible nanoformulation of poorly aqueous soluble APIs by antisolvent precipitation and spray-drying.},
  author={Jun Hu and Wai Kiong Ng and Yuancai Dong and Shoucang Shen and Reginald Beng Hee Tan},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={404 1-2},
  pages={198-204}
}
This work investigates the technical feasibility of formulating water-redispersible nanocrystals of a poorly aqueous soluble drug by a continuous and scalable route. By coupling antisolvent precipitation with immediate spray-drying, fenofibrate nanoparticles were precipitated and formulated into a dry powder form containing lactose or mannitol as redispersant, hydroxylpropyl methyl cellulose (HPMC) and sodium dodecyl sulfate (SDS) as stabilizers. Field emission scanning electron microscopy… CONTINUE READING

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