Continuous amphetamine intoxication: an animal model of the acute psychotic episode.

@article{Ellison1983ContinuousAI,
  title={Continuous amphetamine intoxication: an animal model of the acute psychotic episode.},
  author={Gaylord D. Ellison and Michael S. Eison},
  journal={Psychological medicine},
  year={1983},
  volume={13 4},
  pages={751-61}
}
When amphetamines are administered to humans every few hours for several days, either during the 'speed runs' of addicts or in controlled laboratory settings, the psychosis which reliably results is similar to paranoid schizophrenia in a number of important aspects. This unique regimen of drug intake, which involves the continuous presence of stimulants over a prolonged period of time, can be simulated in animals using subcutaneously implanted slow-release silicone pellets containing d… CONTINUE READING

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