Continuous administration decreases and pulsatile administration increases behavioral sensitivity to a novel dopamine D2 agonist (U-91356A) in MPTP-exposed monkeys.

@article{Blanchet1995ContinuousAD,
  title={Continuous administration decreases and pulsatile administration increases behavioral sensitivity to a novel dopamine D2 agonist (U-91356A) in MPTP-exposed monkeys.},
  author={Pierre J. Blanchet and Fr{\'e}d{\'e}ric Calon and Julien Martel and Paul J. B{\'e}dard and Th{\'e}r{\`e}se Di Paolo and R. E. Walters and Montford F. Piercey},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={272 2},
  pages={854-9}
}
We compared the behavioral effects of a novel and highly selective dopamine D2 receptor agonist, U-91356A, administered to 6 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-exposed parkinsonian monkeys for 27 days following an intermittent (n = 3) or continuous (n = 3) schedule, using subcutaneous osmotic minipumps for the latter group. Each group received equivalent amount of drug daily. Dopamine D1 and D2 receptor binding assays were performed on striatal tissue homogenates with tritiated… CONTINUE READING
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