Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin D

@article{Horwitz2005ContinuousPA,
  title={Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin D},
  author={M. Horwitz and M. Tedesco and S. Sereika and M. A. Syed and A. Garcia-Oca{\~n}a and A. Bisello and B. Hollis and C. Rosen and J. Wysolmerski and P. Dann and C. Gundberg and A. F. Stewart},
  journal={Journal of Bone and Mineral Research},
  year={2005},
  volume={20}
}
  • M. Horwitz, M. Tedesco, +9 authors A. F. Stewart
  • Published 2005
  • Biology, Medicine
  • Journal of Bone and Mineral Research
  • Osteoblast activity and plasma 1,25(OH)2vitamin D are increased in HPT but suppressed in HHM. To model HPT and HHM, we directly compared multiday continuous infusions of PTH versus PTHrP in humans. Continuous infusion of both PTH and PTHrP results in marked and prolonged suppression of bone formation; renal 1,25(OH)2D synthesis was stimulated effectively by PTH but poorly by PTHrP. 
    97 Citations

    Paper Mentions

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