Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan

  title={Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan},
  author={{\AA}sa Johansson and Stefan Enroth and Ulf Gyllensten},
  booktitle={PloS one},
DNA methylation plays an important role in development of disease and the process of aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of white blood cells from a population cohort (N = 421) ranging in age from 14 to 94 years old. Age affects DNA methylation at almost one third (29%) of the sites (Bonferroni adjusted P-value <0.05), of which 60.5% becomes hypomethylated and 39.5% hypermethylated with increasing age. DNA methylation sites that are located… CONTINUE READING
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