Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor.

@article{Swensen2009ContinuousRM,
  title={Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor.},
  author={James S. Swensen and Yi Xiao and Brian Scott Ferguson and Arica A. Lubin and Rebecca Y Lai and Alan J. Heeger and Kevin W. Plaxco and Hyongsok Tom Soh},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 12},
  pages={
          4262-6
        }
}
The development of a biosensor system capable of continuous, real-time measurement of small-molecule analytes directly in complex, unprocessed aqueous samples has been a significant challenge, and successful implementation has been achieved for only a limited number of targets. Toward a general solution to this problem, we report here the Microfluidic Electrochemical Aptamer-based Sensor (MECAS) chip wherein we integrate target-specific DNA aptamers that fold, and thus generate an… CONTINUE READING

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