Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

  title={Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein},
  author={Daeho Park and Claudia Z. Han and Michael R. Elliott and Jason Michael Kinchen and Paul C. Trampont and Soumita Das and Sheila Collins and Jeffrey J. Lysiak and Kyle L Hoehn and Kodi Ravichandran},
Rapid and efficient removal of apoptotic cells by phagocytes is important during development, tissue homeostasis and in immune responses. Efficient clearance depends on the capacity of a single phagocyte to ingest multiple apoptotic cells successively, and to process the corpse-derived cellular material. However, the factors that influence continued clearance by phagocytes are not known. Here we show that the mitochondrial membrane potential of the phagocyte critically controls engulfment… CONTINUE READING
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