Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

@article{Park2011ContinuedCO,
  title={Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein},
  author={Daeho Park and Claudia Z. Han and Michael R. Elliott and Jason Michael Kinchen and Paul C. Trampont and Soumita Das and Sheila Collins and Jeffrey J. Lysiak and Kyle L Hoehn and Kodi Ravichandran},
  journal={Nature},
  year={2011},
  volume={477},
  pages={220-224}
}
Rapid and efficient removal of apoptotic cells by phagocytes is important during development, tissue homeostasis and in immune responses. Efficient clearance depends on the capacity of a single phagocyte to ingest multiple apoptotic cells successively, and to process the corpse-derived cellular material. However, the factors that influence continued clearance by phagocytes are not known. Here we show that the mitochondrial membrane potential of the phagocyte critically controls engulfment… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
54 Citations
32 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 32 references

direct microenvironmental effects of apoptosis in normal and neoplastic tissues

  • C. D. Gregory, Pound, J. D. Cell death in the neighbourhood
  • J. Pathol. 223, 178–195
  • 2011

implications in health and disease

  • M. R. Elliott, Ravichandran, K. S. Clearance of apoptotic cells
  • J. Cell Biol. 189, 1059–1070
  • 2010

Similar Papers

Loading similar papers…