Continued antigen stimulation is not required during CD4(+) T cell clonal expansion.

@article{Lee2002ContinuedAS,
  title={Continued antigen stimulation is not required during CD4(+) T cell clonal expansion.},
  author={William T Lee and Gregory Pasos and Luiza Fosenca Cecchini and James N. Mittler},
  journal={Journal of immunology},
  year={2002},
  volume={168 4},
  pages={1682-9}
}
Peptide Ag initiates CD4(+) T cell proliferation, but the subsequent effects of Ag on clonal expansion are not fully known. In this study, murine CD4(+) T cells were labeled with the fluorescent dye CFSE and were stimulated with specific peptide Ag. Activation occurred, as CFSE-associated fluorescence was reduced 2-fold with each cell division. Separation of proliferating cells based upon CFSE fluorescence intensity showed that daughter cells from each cell division proliferate even after… CONTINUE READING

Connections & Topics

Mentioned Connections BETA
AntigensChemical or drug initiates biological processClonal Anergy
Peptide Ag initiates CD4(+ ) T cell proliferation , but the subsequent effects of Ag on clonal expansion are not fully known .
In this study , murine CD4(+ ) T cells were labeled with the fluorescent dye CFSE and were stimulated with specific peptide Ag .
All Topics