Continual reassessment method: a practical design for phase 1 clinical trials in cancer.

  title={Continual reassessment method: a practical design for phase 1 clinical trials in cancer.},
  author={John O'Quigley and Margaret Sullivan Pepe and Lloyd Fisher},
  volume={46 1},
This paper looks at a new approach to the design and analysis of Phase 1 clinical trials in cancer. The basic idea and motivation behind the approach stem from an attempt to reconcile the needs of dose-finding experimentation with the ethical demands of established medical practice. It is argued that for these trials the particular shape of the dose toxicity curve is of little interest. Attention focuses rather on identifying a dose with a given targeted toxicity level and on concentrating… CONTINUE READING
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