Contingent tolerance to amphetamine hypophagia: new insights into the role of environmental context in the expression of stereotypy

@article{Wolgin2000ContingentTT,
  title={Contingent tolerance to amphetamine hypophagia: new insights into the role of environmental context in the expression of stereotypy},
  author={David L. Wolgin},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2000},
  volume={24},
  pages={279-294}
}
  • D. L. Wolgin
  • Published 1 May 2000
  • Psychology, Biology
  • Neuroscience & Biobehavioral Reviews

Memory Processes Governing Amphetamine-induced Psychomotor Sensitization

Changes in behavioural contingencies produce a loss of tolerance to amphetamine hypophagia in rats despite continued feeding tests while drugged.

TLDR
It is shown that tolerance can also be lost in the face of continued administration of amphetamine prior to milk tests, as a result of changes in the contingencies of reinforcement that govern the suppression of stereotypy.

Changes in behavioural contingencies produce a loss of tolerance to amphetamine hypophagia in rats despite continued feeding tests while drugged

TLDR
It is shown that tolerance can also be lost in the face of continued administration of amphetamine prior to milk tests, as a result of changes in the contingencies of reinforcement that govern the suppression of stereotypy.

Tolerance to amphetamine hypophagia: a real-time depiction of learning to suppress stereotyped movements in the rat.

TLDR
The results support the view that tolerance to amphetamine hypophagia involves a behavioral adaptation to the motor effects of the drug.

Differences between d-methamphetamine and d-amphetamine in rats: working memory, tolerance, and extinction

TLDR
These results indicate that METH and AMPH differ in altering working memory and the expression of tolerance, perhaps due to differences in behavioral inhibition.

Neural substrates of amphetamine induced impulsive behaviour

TLDR
It is demonstrated that different patterns of amphetamine administration produce different effects on the duration of behavioural disinhibition in rats, and further, that amphetamine induced activation of the D2 receptors within the nucleus accumbens core mediates Amphetamine induced behaviouraldisinhibition on the symmetrically reinforced Go/No-go task.

References

SHOWING 1-10 OF 54 REFERENCES

Homeostatic regulation and Pavlovian conditioning in tolerance to amphetamine-induced anorexia.

TLDR
Tolerance to amphetamine-induced anorexia was shown to be both contingent on previous experience with food in the drugged state and subject to Pavlovian control, and proposed that interaction with food is necessary for the homeostatic regulation of disturbances in eating caused by amphetamine.

Effect of prior sensitization of stereotypy on the development of tolerance to amphetamine-induced hypophagia.

TLDR
It is suggested that tolerance may involve the channeling of one form of stereotyped movement into another form (licking of the drinking tube) that represents a constrained form of instrumental learning that is conceptually similar to the behavioral plasticity described in rats receiving electrical brain stimulation or tail pinch.

Sensitization to the psychomotor stimulant effects of amphetamine: modulation by associative learning.

TLDR
The authors investigated the influence of associative pairing of contextual stimuli with amphetamine administration on the expression of psychomotor sensitization, finding that when an amphetamine challenge was given in a test environment that was novel for some groups but not others, theexpression of sensitization was completely context specific.

Tolerance and sensitization to the behavioral effects of drugs.

TLDR
Factors that affect whether tolerance and/or sensitization to the various effects of drugs will develop and be expressed are concerned, and with the variety and levels of mechanisms responsible for tolerance and sensitization under different conditions of exposure.

Role of anorexia and behavioral activation in amphetamine-induced suppression of feeding: implications for understanding tolerance.

TLDR
The results demonstrate that in the normal drinking condition, the initial suppression of intake is caused by a combination of anorexia and behavioral interference and that tolerance occurs to both of these effects.

Learned suppression of stereotypy in amphetamine‐treated rats: implications for understanding tolerance to amphetamine ‘anorexia’

TLDR
It is demonstrated that rats can learn to inhibit amphetamine-induced stereotypy and support the view that tolerance to amphetamine ‘anorexia’ involves learning to suppress stereotyped movements that interfere with feeding.

Amphetamine stereotypy: the influence of environmental factors and prepotent behavioral patterns on its topography and development.

TLDR
Monkeys incorporate components of the initial behaviors associated with amphetamine administration into a wider range of stereotype patterns over months of chronic intoxication, and eventually the stereotypy may evolve into a specific dyskinesia involving movements of the original behavioral component.

Experiential constraints on the development of tolerance to amphetamine hypophagia following sensitization of stereotypy: instrumental contingencies regulate the expression of sensitization

TLDR
It is demonstrated that rats learn to suppress only those stereotyped movements that they experience in the context of feeding and instrumental contingencies can influence the expression of behavioral sensitization.

Tolerance to amphetamine: contingent suppression of stereotypy mediates recovery of feeding.

TLDR
The results suggest that tolerance to the suppression of intake by amphetamine involves learning to suppress stereotyped head movements, and the constraints on such learning are briefly discussed.
...