Contingent tolerance to amphetamine hypophagia: new insights into the role of environmental context in the expression of stereotypy.

@article{Wolgin2000ContingentTT,
  title={Contingent tolerance to amphetamine hypophagia: new insights into the role of environmental context in the expression of stereotypy.},
  author={David L. Wolgin},
  journal={Neuroscience and biobehavioral reviews},
  year={2000},
  volume={24 3},
  pages={279-94}
}
A growing literature attests to the fact that the environment in which a drug is given can have a profound effect on the development and expression of tolerance and sensitization. The dominant paradigm for studying such context-dependency is based on Pavlovian conditioning, in which a distinctive environment serves as a conditioned stimulus. Context dependency is demonstrated when tolerance or sensitization is expressed only in the environment in which the drug was given chronically. An… CONTINUE READING

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