Contextual interactions determine whether the Drosophila homeodomain protein, Vnd, acts as a repressor or activator

@article{Yu2005ContextualID,
  title={Contextual interactions determine whether the Drosophila homeodomain protein, Vnd, acts as a repressor or activator},
  author={Zhongxin Yu and Li-Jyun Syu and Dervla M. Mellerick},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={1 - 12}
}
At the molecular level, members of the NKx2.2 family of transcription factors establish neural compartment boundaries by repressing the expression of homeobox genes specific for adjacent domains [Muhr et al. (2001) Cell, 104, 861-873; Weiss et al. (1998) Genes Dev., 12, 3591-3602]. The Drosophila homologue, vnd, interacts genetically with the high-mobility group protein, Dichaete, in a manner suggesting co-operative activation [Zhao and Skeath (2002) Development, 129, 1165-1174]. However… CONTINUE READING
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