Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: effects on fear-potentiated startle

@inproceedings{GlotzbachSchoon2013ContextualFC,
  title={Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: effects on fear-potentiated startle},
  author={Evelyn Glotzbach-Schoon and Marta Andreatta and Andreas Reif and Heike Ewald and Christian Troeger and Christian Baumann and J{\"u}rgen Deckert and Andreas M{\"u}hlberger and Paul Pauli},
  booktitle={Front. Behav. Neurosci.},
  year={2013}
}
The serotonin (5-HT) and neuropeptide S (NPS) systems are discussed as important genetic modulators of fear and sustained anxiety contributing to the etiology of anxiety disorders. Sustained anxiety is a crucial characteristic of most anxiety disorders which likely develops through contextual fear conditioning. This study investigated if and how genetic alterations of the 5-HT and the NPS systems as well as their interaction modulate contextual fear conditioning; specifically, function… CONTINUE READING

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