Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.

@article{Gibbons2009ContextualEC,
  title={Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.},
  author={Don L. Gibbons and Wei Ju Lin and Chad J Creighton and Zain H. Rizvi and Philip A Gregory and Gregory J. Goodall and Nishan Thilaganathan and Liqin Du and Yiqun Zhang and Alexander Pertsemlidis and Jonathan M. Kurie},
  journal={Genes & development},
  year={2009},
  volume={23 18},
  pages={2140-51}
}
Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here, we address this question by using tumor cell lines derived from mice that develop metastatic lung adenocarcinoma owing to expression of mutant K-ras and p53. Despite having widespread somatic genetic alterations, the metastasis-prone tumor cells retained a marked plasticity. They transited reversibly between epithelial and mesenchymal states, forming… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 190 extracted citations

Similar Papers

Loading similar papers…