Context of deletions and insertions in human coding sequences

  title={Context of deletions and insertions in human coding sequences},
  author={A. Kondrashov and I. Rogozin},
  journal={Human Mutation},
  • A. Kondrashov, I. Rogozin
  • Published 2004
  • Biology, Medicine
  • Human Mutation
  • We studied the dependence of the rate of short deletions and insertions on their contexts using the data on mutations within coding exons at 19 human loci that cause mendelian diseases. We confirm that periodic sequences consisting of three to five or more nucleotides are mutagenic. Mutability of sequences with strongly biased nucleotide composition is also elevated, even when mutations within homonucleotide runs longer than three nucleotides are ignored. In contrast, no elevated mutation rates… CONTINUE READING
    81 Citations

    Topics from this paper

    Sequence context affects the rate of short insertions and deletions in flies and primates
    • 49
    • PDF
    New words in human mutagenesis
    • 16
    • PDF
    Local sequence determinants of two in-frame triplet deletion/duplication hotspots in the RHD/RHCE genes
    • 2
    Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria.
    • 113
    • PDF
    A Macaque's-Eye View of Human Insertions and Deletions: Differences in Mechanisms
    • 59
    • PDF


    Sequence-directed mutagenesis: evidence from a phylogenetic history of human alpha-interferon genes.
    • G. B. Golding, B. Glickman
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1985
    • 35
    • PDF