Context of deletions and insertions in human coding sequences

@article{Kondrashov2004ContextOD,
  title={Context of deletions and insertions in human coding sequences},
  author={A. Kondrashov and I. Rogozin},
  journal={Human Mutation},
  year={2004},
  volume={23}
}
  • A. Kondrashov, I. Rogozin
  • Published 2004
  • Biology, Medicine
  • Human Mutation
  • We studied the dependence of the rate of short deletions and insertions on their contexts using the data on mutations within coding exons at 19 human loci that cause mendelian diseases. We confirm that periodic sequences consisting of three to five or more nucleotides are mutagenic. Mutability of sequences with strongly biased nucleotide composition is also elevated, even when mutations within homonucleotide runs longer than three nucleotides are ignored. In contrast, no elevated mutation rates… CONTINUE READING
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