Context of MUC1 epitope: immunogenicity.

  title={Context of MUC1 epitope: immunogenicity.},
  author={Imelda S. Quinlin and Janet S Burnside and Kenneth E. Dombrowski and Caroline A. Phillips and Nichol Dolby and Shawn E Wright},
  journal={Oncology reports},
  volume={17 2},
MUC1 is a glycoprotein found at the secretory poles of normal cells but is hypoglycosylated on the entire surface of cell membranes of adenocarcinomas. In order to determine the influence on the immune response of peptide context for epitope presentation, peripheral blood mononuclear cells (PBMC) from patients with adenocarcinomas, were stimulated with MUC1 peptides derived from the 20 amino acids (aa) long sequence that is characteristic of the MUC1 Variable Number of Tandem Repeats (VNTR). In… CONTINUE READING