Context is a major determinant of beta-sheet propensity.

@article{Minor1994ContextIA,
  title={Context is a major determinant of beta-sheet propensity.},
  author={Daniel L Minor and Peter S. Kim},
  journal={Nature},
  year={1994},
  volume={371 6494},
  pages={
          264-7
        }
}
Residues in beta-sheets occur in two distinct tertiary contexts: central strands, bordered on both sides by other beta-strands, and edge strands, bordered on only a single side by another beta-strand. The delta delta G values for beta-sheet formation measured at an edge beta-strand of the IgG-binding domain of protein G(GB1) are quite different from those obtained previously at a central position in the same protein. In particular, there is no correlation at the edge position with statistically… CONTINUE READING
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