Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions.

@article{Pelloux2018ContextinducedRT,
  title={Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions.},
  author={Yann Pelloux and Jennifer K. Hoots and Carlo Cifani and Sweta Adhikary and Jennifer Martin and Ang{\'e}lica Minier-Toribio and Jennifer M Bossert and Yavin Shaham},
  journal={Addiction biology},
  year={2018},
  volume={23 2},
  pages={
          699-712
        }
}
We recently developed a rat model of context-induced relapse to alcohol seeking after punishment-imposed abstinence to mimic relapse after self-imposed abstinence due to adverse consequences of drug use. Here, we determined the model's generality to cocaine and have begun to explore brain mechanisms of context-induced relapse to cocaine seeking after punishment-imposed abstinence, using the activity marker Fos. In exp. 1, we trained rats to self-administer cocaine (0.75 mg/kg/infusion, 6 hours… CONTINUE READING
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Published 2017. This article is a U.S. Government work and is in the public domain in the USA

  • Yann Pelloux
  • 2017

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