Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation

@inproceedings{Halu2018ContextenrichedIP,
  title={Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation},
  author={Arda Halu and Jian-guo Wang and Hiromitsu Iwata and Alexander Mojcher and Ana Luisa Abib and Sasha A Singh and Masanori Aikawa and Amitabh Sharma},
  booktitle={eLife},
  year={2018}
}
The role of pro-inflammatory macrophage activation in cardiovascular disease (CVD) is a complex one amenable to network approaches. While an indispensible tool for elucidating the molecular underpinnings of complex diseases including CVD, the interactome is limited in its utility as it is not specific to any cell type, experimental condition or disease state. We introduced context-specificity to the interactome by combining it with co-abundance networks derived from unbiased proteomics… CONTINUE READING
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