Context effects: translation of UAG codon by suppressor tRNA is affected by the sequence following UAG in the message.

@article{Bossi1983ContextET,
  title={Context effects: translation of UAG codon by suppressor tRNA is affected by the sequence following UAG in the message.},
  author={Lionello Bossi},
  journal={Journal of molecular biology},
  year={1983},
  volume={164 1},
  pages={73-87}
}
The efficiency of various suppressor tRNAs in reading the UAG amber codon has been measured at 42 sites in the lacI gene. Results indicate that: (1) for all suppressors, efficiency is not an a priori value; rather, it is determined at each site by the specific reading context of the suppressed codon; (2) the degree of sensitivity to context effects differs among suppressors. Most affected is amber suppressor supE (su2), whose activity varies over a 20-fold range depending on context; (3… CONTINUE READING

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