Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody.

@article{Coxon2010ContextdependentRO,
  title={Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody.},
  author={Angela Coxon and James V. Bready and Hosung Min and Stephen J. Kaufman and Juan Leal and Dongyin Yu and Tani Ann Lee and Ji-Rong Sun and Juan Estrada and Brad N. Bolon and Jonathan C McCabe and Ling Wang and Karen Rex and Sean Caenepeel and Paul Hughes and David H Cordover and Haejin Kim and Seog Joon Han and Mark Leo Michaels and Eric Hsu and Grant T. Shimamoto and Russell C. Cattley and Eunju Hurh and Linh Nguyen and Shao Xiong Wang and Anthony M Ndifor and Isaac J. Hayward and Beverly L. Falc{\'o}n and D M Mcdonald and Luke Li and Tom Boone and Richard Kendall and Robert R Radinsky and Jonathan D. Oliner},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 10},
  pages={2641-51}
}
AMG 386 is an investigational first-in-class peptide-Fc fusion protein (peptibody) that inhibits angiogenesis by preventing the interaction of angiopoietin-1 (Ang1) and Ang2 with their receptor, Tie2. Although the therapeutic value of blocking Ang2 has been shown in several models of tumorigenesis and angiogenesis, the potential benefit of Ang1 antagonism is less clear. To investigate the consequences of Ang1 neutralization, we have developed potent and selective peptibodies that inhibit the… CONTINUE READING

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