Context-dependent regulation of GATA-1 by friend of GATA-1.

  title={Context-dependent regulation of GATA-1 by friend of GATA-1.},
  author={Danielle L Letting and Ying-yu Chen and Carrie Rakowski and Sarah Jane D. Reedy and Gerd A Blobel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 2},
The transcription factor GATA-1 and its cofactor, friend of GATA-1 (FOG-1), are essential for normal erythroid development. FOG-1 physically interacts with GATA-1 to augment or inhibit its activity. The mechanisms by which FOG-1 regulates GATA-1 function are unknown. By using an assay that is based on the phenotypic rescue of a GATA-1-null erythroid cell line, we found that a conditional form of GATA-1 (GATA-1-ER) strongly induced histone acetylation at the beta-major globin promoter in vivo… CONTINUE READING