Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma.

@article{Cox2014ContextdependentFO,
  title={Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma.},
  author={Jesse L Cox and P. J. Wilder and Erin L. Wuebben and Michel M. Ouellette and Michael Anthony Hollingsworth and Angie Rizzino},
  journal={Cancer biology & therapy},
  year={2014},
  volume={15 8},
  pages={1042-52}
}
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadly malignancies. Recently, the deubiquitinating protease USP9X has been shown to behave as an oncogene in a number of neoplasms, including those of breast, brain, colon, esophagus and lung, as well as KRAS wild-type PDAC. However, other studies suggest that USP9X may function as a tumor-suppressor in a murine PDAC model when USP9X expression is depleted during early pancreatic development. To address the conflicting… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS