Context-dependent effects of NMDA receptors on precise timing information at the endbulb of Held in the cochlear nucleus.

@article{Pliss2009ContextdependentEO,
  title={Context-dependent effects of NMDA receptors on precise timing information at the endbulb of Held in the cochlear nucleus.},
  author={Lioudmila Pliss and Hua Yang and Matthew A. Xu-Friedman},
  journal={Journal of neurophysiology},
  year={2009},
  volume={102 5},
  pages={
          2627-37
        }
}
Many synapses contain both AMPA receptors (AMPAR) and N-methyl-d-aspartate receptors (NMDAR), but their different roles in synaptic computation are not clear. We address this issue at the auditory nerve fiber synapse (called the endbulb of Held), which is formed on bushy cells of the cochlear nucleus. The endbulb refines and relays precise temporal information to nuclei responsible for sound localization. The endbulb has a number of specializations that aid precise timing, including AMPAR… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Correlation of AMPA receptor subunit composition with synaptic input in the mammalian cochlear nuclei.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2001
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Development of Primary Axosomatic Endings in the Anteroventral Cochlear Nucleus of Mice

  • Journal of the Association for Research in Otolaryngology
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

High-fidelity transmission acquired via a developmental decrease in NMDA receptor expression at an auditory synapse.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2001
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL