Context-dependent control of alternative splicing by RNA-binding proteins

@article{Fu2014ContextdependentCO,
  title={Context-dependent control of alternative splicing by RNA-binding proteins},
  author={Xiang-Dong Fu and Manuel Ares},
  journal={Nature Reviews Genetics},
  year={2014},
  volume={15},
  pages={689-701}
}
Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative splicing, but it is not yet possible to read the 'splicing code' that dictates splicing regulation on the basis of genome sequence. Each alternative splicing event is controlled by multiple RBPs, the combined action of which creates a distribution of alternatively spliced products in a given cell type. As each cell type expresses a distinct array of RBPs, the interpretation of regulatory information on a given… CONTINUE READING
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