Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells.

@article{Wozniak2007ContextdependentGF,
  title={Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells.},
  author={Ryan J. Wozniak and Meghan E. Boyer and Jeffrey A. Grass and Youngsook Lee and Emery H. Bresnick},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 19},
  pages={14665-74}
}
GATA factors are fundamental components of developmentally important transcriptional networks. By contrast to common mechanisms in which transacting factors function directly at promoters, the hematopoietic GATA factors GATA-1 and GATA-2 often assemble dispersed complexes over broad chromosomal regions. For example, GATA-1 and GATA-2 occupy five conserved regions over approximately 100 kb of the Gata2 locus in the transcriptionally repressed and active states, respectively, in erythroid cells… CONTINUE READING

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