Context and location dependence of adaptive Foxp3(+) regulatory T cell formation during immunopathological conditions.


Circulating Foxp3(+) regulatory T cells (Treg) may arise in the thymus (natural Treg, nTreg) or through the adaptive upregulation of Foxp3 after T cell activation (induced Treg, iTreg). In this brief review, we explore evidence for the formation and function of iTreg during pathologic conditions. Determining the ontogeny and function of Treg populations has… (More)
DOI: 10.1016/j.cellimm.2012.09.009