Context Modulates Outcome of Perinatal Glucocorticoid Action in the Brain

  title={Context Modulates Outcome of Perinatal Glucocorticoid Action in the Brain},
  author={Edo Ronald de Kloet and Sanne E. F. Claessens and Jiska Kentrop},
  booktitle={Front. Endocrinol.},
Prematurely born infants may be at risk, because of inadequate maturation of tissues. If there are signs of preterm birth, it has become common practice therefore to treat either antenatally the mother or postnatally the infant with glucocorticoids to accelerate tissue development, particularly of the lung. However, this life-saving early glucocorticoid treatment was found to increase the risk of adverse outcome in later life. In one animal study, the authors reported a 25% shorter lifespan of… CONTINUE READING
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