Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.

  title={Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.},
  author={Bijal Patel and Damian P. Bright and Martin Mortensen and Bente Fr\olund and Trevor G Smart},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={36 2},
UNLABELLED Tonic GABA currents mediated by high-affinity extrasynaptic GABAA receptors, are increasingly recognized as important regulators of cell and neuronal network excitability. Dysfunctional GABAA receptor signaling that results in modified tonic GABA currents is associated with a number of neurological disorders. Consequently, developing compounds to selectively modulate the activity of extrasynaptic GABAA receptors underlying tonic inhibition is likely to prove therapeutically useful… CONTINUE READING


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