Context- and Cell-Dependent Effects of Delta-Like 4 Targeting in the Bone Marrow Microenvironment

Abstract

Delta-like 4 (Dll4) is a ligand of the Notch pathway family which has been widely studied in the context of tumor angiogenesis, its blockade shown to result in non-productive angiogenesis and halted tumor growth. As Dll4 inhibitors enter the clinic, there is an emerging need to understand their side effects, namely the systemic consequences of Dll4:Notch… (More)
DOI: 10.1371/journal.pone.0052450

Topics

1 Figure or Table

Statistics

020406080201520162017
Citations per Year

Citation Velocity: 11

Averaging 11 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.

Cite this paper

@inproceedings{Remdio2012ContextAC, title={Context- and Cell-Dependent Effects of Delta-Like 4 Targeting in the Bone Marrow Microenvironment}, author={Leonor Rem{\'e}dio and T. C. M. B. Carvalho and Francisco Caiado and Ana Bastos-Carvalho and Diana Lopes Lacerda Martins and Ant{\'o}nio Duarte and Hideo Yagita and S{\'e}rgio Dias}, booktitle={PloS one}, year={2012} }