Content of oak moss allergens atranol and chloroatranol in perfumes and similar products

@article{Rastogi2004ContentOO,
  title={Content of oak moss allergens atranol and chloroatranol in perfumes and similar products},
  author={Suresh Chandra Rastogi and Rossana Bossi and Jeanne Duus Johansen and Torkil Menn{\'e} and Guillaume Bernard and Elena Gim{\'e}nez-Arnau and Jean‐Pierre Lepoittevin},
  journal={Contact Dermatitis},
  year={2004},
  volume={50}
}
Chloroatranol and atranol have been identified as the main allergens in the fragrance material of botanical origin, oak moss absolute. A previous study has shown that nearly all individuals sensitized to chloroatranol will elicit to 5 μg/ml. in a repeated open application test and that 50% will get a reaction to 0.15 µg/ml under patch test conditions. Thus, chloroatranol is known as a potent allergen. The aim of the current investigation was to quantify exposure to chloroatranol and the… 
Comparison of elicitation potential of chloroatranol and atranol – 2 allergens in oak moss absolute
TLDR
It is concluded that the differences in elicitation capacity between the 2 substances are counterbalanced by exposure being greater to atranol than to chloroatranol and that both substances contribute to the clinical problems seen in oak moss absolute‐sensitized individuals.
Usage tests of oak moss absolutes containing high and low levels of atranol and chloroatranol.
TLDR
The ROAT indicates that the use of a cosmetic product containing oak moss absolute with reduced levels of atranol and chloroatranol is capable of eliciting an allergic reaction in previously sensitised individuals.
Are atranols the only skin sensitizers in oakmoss? A systematic investigation using non-animal methods.
Selected important fragrance sensitizers in perfumes – current exposures
TLDR
A significant decrease in the frequency of presence of chloroatranol in the products was observed, indicating there is still a wide‐spread exposure to potent fragrance allergens in perfumes.
Enzyme-Catalysed Conversion of Atranol and Derivatives into Dimeric Hydrosoluble Materials: Application to the Preparation of a Low-Atranol Oakmoss Absolute
Oakmoss absolute, a solvent extract from Evernia prunastri, is a valuable fragrance ingredient widely used in fine fragrance for almost two centuries. Some minor components of oakmoss absolute, such
Contact allergy to fragrances with a focus on oak moss absolute
The exposure to fragrances is widespread and contact allergy to fragrance substances affects 1–4% of the general population. Many fragrance substances are volatile and it can therefore be suspected
Bio-Guided Fractionation and Identification of Allergens in Complex Mixtures and Products
TLDR
In this chapter, a methodology based on the combination of bioassay-guided chemical fractionation, patch test and/or use testing of individuals with fractions, detailed chemical composition analysis of positive fractions, and chemical structure-activity relationship analysis of identified molecules is presented as a valuable tool for the identification of allergens in complex mixtures.
Lichen extracts as raw materials in perfumery. Part 2: treemoss
This is a comprehensive review of extracts from the lichen Pseudevernia furfuracea (treemoss) that are used in the fragrance industry. Qualitative and quantitative analytical aspects are critically
Identification of Allergens in Complex Mixtures and Products
Identifying contact allergens among the myriad of chemicals used in commercial products is an extremely arduous task. This is even more difficult in the case of components of complex mixtures such as
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References

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Chloroatranol, an extremely potent allergen hidden in perfumes: a dose‐response elicitation study
TLDR
In conclusion, the hidden exposure to a potent allergen widely used in perfumes has caused a highly sensitized cohort of individuals to develop an allergic reaction.
Contact allergy to oak moss: search for sensitizing molecules using combined bioassay-guided chemical fractionation, GC-MS, and structure-activity relationship analysis
TLDR
Methyl-β-orcinol carboxylate, a depside degradation product and the most important monoaryl derivative of oak moss from an olfactory standpoint, was found to elicit a reaction in most patients, and atranol and chloroatranol, formed by transesterification and decarboxylation of the lichen depsides, are strong elicitants in most Patients sensitized to oak moss.
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TLDR
A validated liquid chromatographic-tandem mass spectrometric method for quantitative analysis of the potential oak moss allergens atranol and chloroatranol in perfumes and similar products allowed identification of these compounds at concentrations below those causing allergic skin reactions in oak-moss-sensitive patients.
Atranorin and oak moss contact allergy
TLDR
The patient had thus contracted her contact allergies both from the repamng preparation and the ingredients in the sand cores, with a small amount of formaldehyde.
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TLDR
The incidence of a concomitant positive patch test to balsam of Peru in fragrance‐sensitive patients showed wide variation, suggesting that it is not a reliable marker of fragrance allergy.
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Oakmoss absolute, an extract of the lichen Evernia prunastri, is known to cause allergenic skin reactions due to the presence of certain aromatic aldehydes such as atranorin, chloratranorin, ethyl
The frequency of fragrance allergy in patch test population over 17 years
  • Br J Dermatol
  • 2000
Table 1. Content of atranol and chloroatranol in the investigated products Content (mg/ml)*
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