Content Tuning in the Medial Temporal Lobe Cortex: Voxels that Perceive, Retrieve

  title={Content Tuning in the Medial Temporal Lobe Cortex: Voxels that Perceive, Retrieve},
  author={Heidrun Schultz and Roni Tibon and Karen F. LaRocque and Stephanie A. Gagnon and Anthony D. Wagner and Bernhard P. Staresina},
Abstract How do we recall vivid details from our past based only on sparse cues? Research suggests that the phenomenological reinstatement of past experiences is accompanied by neural reinstatement of the original percept. This process critically depends on the medial temporal lobe (MTL). Within the MTL, perirhinal cortex (PRC) and parahippocampal cortex (PHC) are thought to support encoding and recall of objects and scenes, respectively, with the hippocampus (HC) serving as a content… 
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Reversible Information Flow across the Medial Temporal Lobe: The Hippocampus Links Cortical Modules during Memory Retrieval
Functional integration between these MTL regions during successful memory retrieval is demonstrated, with reversible signal flow from the cue region to the target region via the hippocampus, supporting the claim that the human hippocampus provides the vital associative link that integrates information held in different parts of cortex.
Content-specific source encoding in the human medial temporal lobe.
  • T. Awipi, L. Davachi
  • Psychology, Biology
    Journal of experimental psychology. Learning, memory, and cognition
  • 2008
It was found that encoding activation in the right perirhinal cortex correlates with successful recollection of the paired object, and other MTL subregions also exhibited content-specific source encoding patterns of activation, suggesting that MTL subsequent memory effects are sensitive to stimulus category.
Perirhinal and Parahippocampal Cortices Differentially Contribute to Later Recollection of Object- and Scene-Related Event Details
The results strongly point to representational domain as a key factor determining the involvement of different MTLC subregions during successful episodic memory formation.
Medial temporal lobe reinstatement of content-specific details predicts source memory
Category‐specificity in the human medial temporal lobe cortex
Measuring differential BOLD responsiveness to objects, scenes, and other stimulus categories, an anatomical ROI based approach was undertaken in an effort to understand the response profile underlying a double dissociation between an anterior PRc response to objects and a posterior PHC response to scene stimuli.
High-resolution fMRI of Content-sensitive Subsequent Memory Responses in Human Medial Temporal Lobe
The present data suggest a gradient of content sensitivity from posterior (parahippocampal) to anterior (perirhinal) MTL cortex, with MTL cortical regions differentially contributing to successful encoding based on event content.
Medial temporal lobe contributions to cued retrieval of items and contexts
Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans
A conceptual model of how object and spatial interference are reduced in the regions providing input to the hippocampus, allowing rich, distinct memories to be built is proposed, and novel evidence for a domain-selective dissociation between lateral and medial entorhinal cortex in humans and between perirhinal and parahippocampal cortex as a function of information content is demonstrated.
The medial temporal lobe and recognition memory.
Evidence from neuropsychological, neuroimaging, and neurophysiological studies of humans, monkeys, and rats indicates that different subregions of the MTL make distinct contributions to recollection and familiarity; the data suggest that the hippocampus is critical for recollection but not familiarity.
Episodic Reinstatement in the Medial Temporal Lobe
It is shown that neural activity patterns for unique word-scene combinations encountered during encoding are reinstated in human parahippocampal cortex (PhC) during retrieval, consistent with a role of the hippocampus in coordinating pattern completion in cortical regions.