Contemporary concepts of migraine pathogenesis.

@article{Welch2003ContemporaryCO,
  title={Contemporary concepts of migraine pathogenesis.},
  author={Kenneth Michael A Welch},
  journal={Neurology},
  year={2003},
  volume={61 8 Suppl 4},
  pages={
          S2-8
        }
}
The pathogenesis of migraine is incompletely understood. Recent discoveries have shed light on the neuronal events mediating both the aura and the headache phases of migraine, identifying a cerebral cortical origin of migraine aura, susceptibility to attacks based on cortical hyperexcitability, and headache originating in the trigeminovascular system and its central projections. Abnormal modulation of brain nociceptive systems, at first transient but becoming permanent with continuing illness… CONTINUE READING
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