Contemporary Issues in Chronic Pain Management

@inproceedings{Parris2012ContemporaryII,
  title={Contemporary Issues in Chronic Pain Management},
  author={Winston C. V. Parris},
  booktitle={Current Management of Pain},
  year={2012}
}
  • W. Parris
  • Published in Current Management of Pain 21 October 2012
  • Medicine
View on Springer
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14 Citations
Background Citations
2

14 Citations

Chapter 2 History of Ion Channels in the Pain Sensory System

Effects of the somatostatin receptor subtype 4 selective agonist J‐2156 on sensory neuropeptide release and inflammatory reactions in rodents

The effects of a high affinity, sst4‐selective, synthetic agonist, J‐2156, on sensory neuropeptide release in vitro and inflammatory processes in vivo are investigated.

Hot peppers, pain and analgesics

The hot pepper, or more precicely capsaicin, the hot component of chilli peppers of the Capsicum family, was the key that opened new horizons in the field of analgesics and the pharmacology of…

Gastric mucosal integrity: gastric mucosal blood flow and microcirculation. An overview

Anti-nociceptive effect induced by somatostatin released from sensory nerve terminals and by synthetic somatostatin analogues in the rat

Substance P

The current knowledge about the function of substance P in pain is reviewed and special emphasis is put on how to use this knowledge in the development of new ways to treat pain.

Naturally occurring antinociceptive substances from plants

Despite the progress that has occurred in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain. One of…

Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents

Capsaicin and the stomach. A review of experimental and clinical data

Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes.

References

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Capsaicin as a cutaneous stimulus: sensitivity and sensory qualities on hairy skin

The influence of common food additives and temperature on threshold perception of capsaicin

Etude du role du glucose, du chlorure de sodium, de l'acide citrique a differentes concentrations en solutions aqueuses presentees a 2, 18 ou 60 o C dans les variations du seuil de perception de la…

Substance P: From extract to excitement*

Capsaicin-sensitive cutaneous sense organs: Nerve terminals with multiple funcions

Neurotoxic effect of capsaicin in mammals.

Recent studies furnished evidence for a selective neurodegenerative action of systemically injected capsaicin in adult mammals, as well, indicating that some of the irreversible functional impairments produced by capsaicIn in adult animals may result from the degeneration of a particular subpopulation of CPSNs.

Intraneural microstimulation in man. Its relation to specificity of tactile sensations.

It is concluded that the human brain has an exquisite capacity to detect, localize, delineate, and classify sensations from the input of individual tactile units in the glabrous skin of the hand.

The sensory-efferent function of capsaicin-sensitive sensory neurons.

Somatostatin in human cerebrospinal fluid.

The wide variety of diseases with somatostatin elevation suggests nonspecific leakage from damaged brain tissue, and Cerebrospinal-fluid som atostatin may provide a good index of brain damage.

Capsaicin prevents histamine-induced itching.

It is concluded that, in addition to the axon reflex flare, capsaicin-sensitive peptide-containing primary afferent neurones are also intimately involved in the mediation of the sensation of itching.

VASCULAR AND SENSORY RESPONSES OF HUMAN SKIN TO MILD INJURY AFTER TOPICAL TREATMENT WITH CAPSAICIN

Over a period from several days to several weeks after treatment, flare was diminished and heat pain thresholds were slightly elevated, which may be due to long‐lasting damage of cutaneous nerve terminals by capsaicin.
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