Contemporary Issues in Chronic Pain Management

  title={Contemporary Issues in Chronic Pain Management},
  author={Winston C. V. Parris},
  booktitle={Current Management of Pain},
  • W. Parris
  • Published in Current Management of Pain 21 October 2012
  • Medicine

Effects of the somatostatin receptor subtype 4 selective agonist J‐2156 on sensory neuropeptide release and inflammatory reactions in rodents

The effects of a high affinity, sst4‐selective, synthetic agonist, J‐2156, on sensory neuropeptide release in vitro and inflammatory processes in vivo are investigated.

Hot peppers, pain and analgesics

The hot pepper, or more precicely capsaicin, the hot component of chilli peppers of the Capsicum family, was the key that opened new horizons in the field of analgesics and the pharmacology of

Substance P

The current knowledge about the function of substance P in pain is reviewed and special emphasis is put on how to use this knowledge in the development of new ways to treat pain.

Naturally occurring antinociceptive substances from plants

Despite the progress that has occurred in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain. One of



The influence of common food additives and temperature on threshold perception of capsaicin

Etude du role du glucose, du chlorure de sodium, de l'acide citrique a differentes concentrations en solutions aqueuses presentees a 2, 18 ou 60 o C dans les variations du seuil de perception de la

Substance P: From extract to excitement*

Neurotoxic effect of capsaicin in mammals.

Recent studies furnished evidence for a selective neurodegenerative action of systemically injected capsaicin in adult mammals, as well, indicating that some of the irreversible functional impairments produced by capsaicIn in adult animals may result from the degeneration of a particular subpopulation of CPSNs.

Intraneural microstimulation in man. Its relation to specificity of tactile sensations.

It is concluded that the human brain has an exquisite capacity to detect, localize, delineate, and classify sensations from the input of individual tactile units in the glabrous skin of the hand.

The sensory-efferent function of capsaicin-sensitive sensory neurons.

Somatostatin in human cerebrospinal fluid.

The wide variety of diseases with somatostatin elevation suggests nonspecific leakage from damaged brain tissue, and Cerebrospinal-fluid som atostatin may provide a good index of brain damage.

Capsaicin prevents histamine-induced itching.

It is concluded that, in addition to the axon reflex flare, capsaicin-sensitive peptide-containing primary afferent neurones are also intimately involved in the mediation of the sensation of itching.


Over a period from several days to several weeks after treatment, flare was diminished and heat pain thresholds were slightly elevated, which may be due to long‐lasting damage of cutaneous nerve terminals by capsaicin.