Contemporaneous fluctuations in T cell responses to persistent herpes virus infections.

@article{Crough2005ContemporaneousFI,
  title={Contemporaneous fluctuations in T cell responses to persistent herpes virus infections.},
  author={Tania Crough and Jacqueline M. Burrows and Chrysa Fazou and Susan Walker and Miles P. Davenport and Rajiv Khanna},
  journal={European journal of immunology},
  year={2005},
  volume={35 1},
  pages={139-49}
}
The classical paradigm for T cell dynamics suggests that the resolution of a primary acute virus infection is followed by the generation of a long-lived pool of memory T cells that is thought to be highly stable. Very limited alteration in this repertoire is expected until the immune system is re-challenged by reactivation of latent viruses or by cross-reactive pathogens. Contradicting this view, we show here that the T cell repertoire specific for two different latent herpes viruses in the… CONTINUE READING