Contamination of nanoparticles by endotoxin: evaluation of different test methods

@inproceedings{Smulders2012ContaminationON,
  title={Contamination of nanoparticles by endotoxin: evaluation of different test methods},
  author={Stijn Smulders and Jean-Pierre Kaiser and S. Zuin and Kirsten L van Landuyt and Luana Golanski and Jeroen A. J. Vanoirbeek and Peter Wick and Peter Hm Hoet},
  booktitle={Particle and Fibre Toxicology},
  year={2012}
}
Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanoparticle samples. We assessed the reliability of the commonly used limulus amebocyte lysate (LAL) assay and an alternative method based on toll-like receptor (TLR) 4 reporter cells when applied with particles (TiO2, Ag, CaCO3 and SiO2), or after extraction of the endotoxin as described in… CONTINUE READING
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