Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis

  title={Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis},
  author={Anita A. Thambirajah and Emily M. Koide and Jacob J. Imbery and Caren C. Helbing},
  journal={Frontiers in Endocrinology},
Aquatic and terrestrial environments are increasingly contaminated by anthropogenic sources that include pharmaceuticals, personal care products, and industrial and agricultural chemicals (i. e., pesticides). Many of these substances have the potential to disrupt endocrine function, yet their effect on thyroid hormone (TH) action has garnered relatively little attention. Anuran postembryonic metamorphosis is strictly dependent on TH and perturbation of this process can serve as a sensitive… 

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