Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

@article{Hoelscher2008ContainmentOA,
  title={Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.},
  author={Christoph Hoelscher and Norbert Reiling and Ulrich Emil Schaible and Alexandra H{\"o}lscher and Clara Bathmann and Daniel Korbel and Insa Lenz and Tanja Sonntag and Svenja Kr{\"o}ger and Shizuo Akira and Horst Mossmann and Carsten J Kirschning and Hermann Wagner and Marina A. Freudenberg and Stefan Ehlers},
  journal={European journal of immunology},
  year={2008},
  volume={38 3},
  pages={680-94}
}
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (Mtb) infection remains controversial. To address the impact of TLR-mediated pathogen recognition and MyD88-dependent signaling events on anti-mycobacterial host responses, we analyzed the outcome of Mtb infection in TLR2/4/9 triple- and MyD88-deficient mice. After aerosol infection, both TLR2/4/9-deficient and wild-type mice expressed pro-inflammatory cytokines promoting antigen-specific T cells… CONTINUE READING