Contacts with fibrils containing collagen I, but not collagens II, IX, and XI, can destabilize the cartilage phenotype of chondrocytes.

@article{Farjanel2001ContactsWF,
  title={Contacts with fibrils containing collagen I, but not collagens II, IX, and XI, can destabilize the cartilage phenotype of chondrocytes.},
  author={Jean Farjanel and Guido Schuermann and Peter Bruckner},
  journal={Osteoarthritis and cartilage},
  year={2001},
  volume={9 Suppl A},
  pages={S55-63}
}
OBJECTIVE Cell-matrix interactions are important regulators of cellular functions, including matrix synthesis, proliferation and differentiation. This is well exemplified by the characteristically labile phenotype of chondrocytes that is lost in monolayer culture but is stabilized in suspension under appropriate conditions. We were interested in the role of collagen suprastructures in maintaining or destabilizing the cartilage phenotype of chondrocytes. DESIGN Primary sternal chondrocytes… CONTINUE READING
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