Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals.

@article{Derfuss2009Contactin2TAG1directedAI,
  title={Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals.},
  author={Tobias J Derfuss and Khyati Parikh and Sviataslau Velhin and Magdalena Braun and Emily Mathey and Markus Krumbholz and Tania Kuempfel and Anja I. S. Moldenhauer and Christoph Rader and Peter Sonderegger and Walter P{\"o}llmann and Christian Tiefenthaller and Jan Niklas Bauer and Hans Lassmann and Hartmut Wekerle and Domna Karagogeos and Reinhard Hohlfeld and Christopher Linington and Edgar Meinl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 20},
  pages={8302-7}
}
Gray matter pathology is increasingly recognized as an important feature of multiple sclerosis (MS), but the nature of the immune response that targets the gray matter is poorly understood. Starting with a proteomics approach, we identified contactin-2/transiently expressed axonal glycoprotein 1 (TAG-1) as a candidate autoantigen recognized by both autoantibodies and T helper (Th) 1/Th17 T cells in MS patients. Contactin-2 and its rat homologue, TAG-1, are expressed by various neuronal… CONTINUE READING
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