Contact with a component of the polymerase II holoenzyme suffices for gene activation

@article{Barberis1995ContactWA,
  title={Contact with a component of the polymerase II holoenzyme suffices for gene activation},
  author={Alcide Barberis and Joseph Pearlberg and N Simkovich and Susan Farrell and Pamela Reinagel and Cynthia Bamdad and George B. Sigal and Mark Ptashne},
  journal={Cell},
  year={1995},
  volume={81},
  pages={359-368}
}
  • Alcide Barberis, Joseph Pearlberg, +5 authors Mark Ptashne
  • Published in Cell 1995
  • Biology, Medicine
  • In yeast strains bearing the point mutation called GAL11P (for potentiator), certain GAL4 derivatives lacking any classical activating region work as strong activators. The P mutation confers upon GAL11, a component of the RNA polymerase II holoenzyme, the ability to interact with a portion of the dimerization region of GAL4. The region of GAL11 affected by the P mutation is evidently functionally inert in ordinary cells, suggesting that this mutation is of no functional significance beyond… CONTINUE READING

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