Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha.

@article{Parry1997ContactWT,
  title={Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha.},
  author={Sarah Louise Parry and M Sebbag and Marc Feldmann and Fionula Mary Brennan},
  journal={Journal of immunology},
  year={1997},
  volume={158 8},
  pages={3673-81}
}
IL-10, originally described as a cytokine synthesis inhibitory factor, is secreted by a number of cells of the immune system, including monocytes and T cells. IL-10 is a potent inhibitor of monocyte/macrophage activation, and we have shown previously this cytokine to be a major endogenous down-regulator of TNF-alpha in the rheumatoid joint. The mechanisms involved in regulating IL-10 production by cells of the monocyte/macrophage lineage are not yet clear, and most studies to date have used an… CONTINUE READING
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