Contact sensitivity to DNCB in normal and cell-mediated-immunity deficient chickens: in vivo detection and correlation with lymphocyte transformation and graft-versus-host reaction.

@article{Tiwary1985ContactST,
  title={Contact sensitivity to DNCB in normal and cell-mediated-immunity deficient chickens: in vivo detection and correlation with lymphocyte transformation and graft-versus-host reaction.},
  author={B K Tiwary and Mahesh C Goel},
  journal={Veterinary immunology and immunopathology},
  year={1985},
  volume={8 4},
  pages={329-39}
}
Optimum conditions for the contact sensitivity (CS) test using 2,4-dinitrochlorobenzene (DNCB) were sensitization with 0.25 ml of a DNCB solution (10 mg/ml) and challenge with one-tenth of this dose two weeks later. This produced reaction in terms of skin thickness which could be easily observed and measured. The cutaneous hypersensitivity developed slowly, reaching its maximum manifestation after 24 h of challenge and gradually declining thereafter. The development of a skin reaction was… CONTINUE READING

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