• Corpus ID: 246016142

Contact-mediated signaling enables disorder-driven transitions in cellular assemblies

@inproceedings{Kuyyamudi2022ContactmediatedSE,
  title={Contact-mediated signaling enables disorder-driven transitions in cellular assemblies},
  author={Chandrashekar Kuyyamudi and Shakti N. Menon and Sitabhra Sinha},
  year={2022}
}
We show that when cells communicate by contact-mediated interactions, heterogeneity in cell shapes and sizes leads to qualitatively distinct collective behavior in the tissue. For inter-cellular coupling that implements lateral inhibition, such disorder-driven transitions can substantially alter the asymptotic pattern of differentiated cells by modulating their fate choice through changes in the neighborhood geometry. In addition, when contact-induced signals influence inherent cellular… 

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